Electronic Monitoring of Adherence to Inhaled Medication in Asthma

Posted on: 11 June 2015 By: jesica111

The main treatment of asthma is inhaled corticosteroids. However adherence to these medications in asthma is often poor, with low adherence associated with excessive health care costs and an increased risk of emergency room visits and mortality. Although various methods are used to indirectly assess adherence, all have significant limitations whether used in clinical or research practice. The recent development of electronic monitoring devices (EMDs) for use with inhalers presents an exciting opportunity to easily and accurately measure inhaler adherence.

Cough and Asthma

Posted on: 09 June 2015 By: jesica111

Cough is the most common complaint for which patients seek medical attention. Cough variant asthma (CVA) is a form of asthma, which presents solely with cough. CVA is one of the most common causes of chronic cough. More importantly, 30 to 40% of adult patients with CVA, unless adequately treated, may progress to classic asthma. CVA shares a number of pathophysiological features with classic asthma such as atopy, airway hyper-responsiveness, eosinophilic airway inflammation and various features of airway remodeling.

It’s a Great Day to be a CHAMP

Posted on: 08 June 2015 By: susan steppe
Susan Steppe, the Project Director of CHAMP, discusses winning the 2015 National Environmental Leadership Award in Asthma Management and her program's work to serve a subset of asthma patients, focusing on children who are most at risk for multiple or severe asthma exacerbations that would result in unplanned medical encounters in the emergency department or hospital.

Recent Advances in Asthma Genetics and Antiasthma Therapy

Posted on: 05 June 2015 By: jesica111

Asthma is a pathophysiological condition associated with eosinophilia and heightened inflammatory reactions, epithelial desquamation, hyper responsiveness, recurring episodes of reversible broncho-constriction, and mucus hyper secretion from the respiratory organs. Asthma interludes can be triggered by a variety of factors most notably allergens, infectious agents, pollutants, and nonspecific stimuli such as exercise, nutritional factors and emotional stress. Certain genes and their polymorphism may also have effects in the initiation and progression of asthma.

The Basement Membrane Zone in Asthma: The Supracellular Anchoring Network

Posted on: 05 June 2015 By: jesica111

Thickening of the basement membrane zone (BMZ) is a characteristic feature of airway remodeling in the lungs of asthmatics. However the significance of a thickened BMZ in the pathology of the asthmatic airway is not known. In this review we show that the columnar epithelium is linked to the reticular BMZ through the supracellular anchoring network. We discuss the evidence that changes in the width of the BMZ in control airways are part of a supracellular anchoring mechanism for increasing the strength of attachment between the airway epithelium and the extracellular matrix (ECM).

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